Who won the last matchup between the 49ers and Colts?

The 49ers have dominated recent matchups against the Colts. In their most recent meeting (2023), San Francisco won 30-18. The 49ers have won 7 of the last 10 games between these franchises, reflecting their superior overall performance in recent seasons.

Why are the 49ers considered favorites over the Colts?

The 49ers are favored due to their elite defense (ranked top-5), proven coaching system, recent Super Bowl championship, and consistent playoff appearances. The Colts are still in rebuilding mode with a younger roster and coaching staff, making them less predictable contenders.

What is each team's main offensive strength?

The 49ers excel with a dominant rushing attack (134+ yards per game) complemented by play-action passing, built around their run game philosophy. The Colts emphasize passing efficiency (287+ yards per game) with mobile quarterback play designed to create explosive plays through the air.

How have injuries affected each team's 2025 season?

The 49ers have dealt with consistent injury challenges to key defensive and offensive players but maintained elite status. The Colts have experienced fewer high-profile injuries but still struggle with depth and consistency across the roster.

Which team is better for fantasy football purposes?

The 49ers offer more consistent defensive scoring and proven offensive weapons with higher volume stats. The Colts provide higher-ceiling passing plays with their QB-centric offense but lower floor consistency, making them better for risk-tolerant fantasy players.

San Francisco 49ers vs Indianapolis Colts

Updated March 28, 2026

San Francisco 49ers

NFC West powerhouse known for defensive strength and strategic roster management

Fans seeking a legitimate Super Bowl contender with proven execution

Check Price

Indianapolis Colts

AFC South franchise rebuilding with quarterback development focus

Fans who appreciate rebuilding upside and patience with developing talent

Short Answer

The 49ers are an NFC West powerhouse known for strong defense and running game, while the Colts compete in the AFC South with a focus on quarterback development and offensive playmaking. Both teams have rich histories but differ significantly in recent performance and roster composition.

Our Verdict

The 49ers currently hold the advantage as an elite contender with recent Super Bowl success, elite defense, and proven coaching stability under Kyle Shanahan. The Colts are rebuilding with a younger coaching staff and developing roster but lack recent postseason success. The choice depends on whether you value established excellence or upside potential.

San Francisco 49ers9.4

5.6Indianapolis Colts

Choose San Francisco 49ers if

Fans seeking a legitimate Super Bowl contender with proven execution

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Key Differences at a Glance

🔹

Conference: NFC West vs AFC South

🔹

Recent Playoff Success: San Francisco 49ers wins (Super Bowl LVIII Appearance (2023) vs Playoff Drought (Last playoff appearance 2020))

🔹

Defensive Ranking (2025): San Francisco 49ers wins (Top 5 Defense vs Mid-tier Defense)

See all 7 differences

Key Facts & Figures

Metric	San Francisco 49ers	Indianapolis Colts	Diff
Points Per Game (Offense)(PPG)	26.3	23.1	+14%
Points Allowed Per Game (Defense)(PPG)	18.2	24.7	-26%
Rushing Yards Per Game(yards)	134.2

Key Differences

San Francisco 49ers

Attribute

Indianapolis Colts

NFC West

Conference

AFC South

Super Bowl LVIII Appearance (2023)🏆

Recent Playoff Success

Playoff Drought (Last playoff appearance 2020)

Top 5 Defense🏆

Defensive Ranking (2025)

Mid-tier Defense

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Last updated: March 28, 2026AI generated

Conference

San Francisco 49ers

NFC West

Indianapolis Colts

AFC South

Recent Playoff Success

San Francisco 49ers

Super Bowl LVIII Appearance (2023)🏆

Indianapolis Colts

Playoff Drought (Last playoff appearance 2020)

Defensive Ranking (2025)

San Francisco 49ers

Top 5 Defense🏆

Indianapolis Colts

Mid-tier Defense

Head Coach Tenure

San Francisco 49ers

Kyle Shanahan (7 seasons)🏆

Indianapolis Colts

Shane Steichen (2 seasons)

Offensive Philosophy

San Francisco 49ers

Run-heavy with play-action passes

Indianapolis Colts

Pass-first with mobile QB emphasis

Super Bowl Wins

San Francisco 49ers

5 total (1994, 1995, 1997, 2019, 2023)🏆

Indianapolis Colts

1 total (2006)

Stadium Capacity

San Francisco 49ers

Levi's Stadium - 75,000🏆

Indianapolis Colts

Lucas Oil Stadium - 67,000

Full Comparison

Attribute	San Francisco 49ers	Indianapolis Colts

2025 Win-Loss Record(wins-losses)	13-4	8-9
Playoff Appearances (Last 5 Years)(appearances)	4	0
2025 Season Wins(wins)	12	—

Points Per Game (Offense)(PPG)	26.3	23.1

Points Allowed Per Game (Defense)(PPG)	18.2	24.7
Points Allowed Per Game (2025)(points)	18.9	—

Rushing Yards Per Game(yards)	134.2	108.6
Passing Yards Per Game(yards)	259.8	287.3
Average Passing Yards Per Game (2025)(yards)	234.2	—
Average Rushing Yards Per Game (2025)(yards)	148.7	—

Head Coach Winning Percentage(%)	71.4%	56.3%

Franchise Super Bowl Wins(total)	5	1
Super Bowl Appearances(total)	6	—

Head Coach Win Percentage(percent)	63.2%	—

Playoff Wins (Last 3 Seasons)(wins)	6	—

Team Payroll (2025 Approx)(millions)	$267M	—

Turnovers(count)	0	—
Fumbles Lost(count)	0	—
Total Turnovers (Fumbles + INTs)(count)	0	—
Fumbles (Total-Lost)(count)	0-0	—

Yards Per Play(yards)	3.9	—

Interceptions Thrown(count)	0	—

2026 Roster Building Moves(deals)	14 reserve/future deals	—

Game Execution Rating(score)	Excellent - Clean execution	—
Win-Loss Record (2025 Season)(Record)	7-6	—

Points Per Game (2025 Season)(PPG)	24.3	—
Rushing Yards Per Game (2025 Season)(YPG)	108.2	—
Passing Yards Per Game (2025 Season)(YPG)	285.9	—

Points Allowed Per Game (2025 Season)(PPG)	22.8	—
Sacks Per Game (2025 Season)(SPG)	2.1	—
Turnovers Forced (2025 Season)(Total)	18	—

Third Down Conversion Rate (2025)(%)	42.1%	—

San Francisco 49ers

Indianapolis Colts

2025 Win-Loss Record(wins-losses)

13-4

8-9

Playoff Appearances (Last 5 Years)(appearances)

2025 Season Wins(wins)

—

Points Per Game (Offense)(PPG)

26.3

23.1

Points Allowed Per Game (Defense)(PPG)

18.2

24.7

Points Allowed Per Game (2025)(points)

18.9

—

Rushing Yards Per Game(yards)

134.2

108.6

Passing Yards Per Game(yards)

259.8

287.3

Average Passing Yards Per Game (2025)(yards)

234.2

—

Average Rushing Yards Per Game (2025)(yards)

148.7

—

Head Coach Winning Percentage(%)

71.4%

56.3%

Franchise Super Bowl Wins(total)

Super Bowl Appearances(total)

—

Head Coach Win Percentage(percent)

63.2%

—

Playoff Wins (Last 3 Seasons)(wins)

—

Team Payroll (2025 Approx)(millions)

$267M

—

Turnovers(count)

—

Fumbles Lost(count)

—

Total Turnovers (Fumbles + INTs)(count)

—

Fumbles (Total-Lost)(count)

0-0

—

Yards Per Play(yards)

3.9

—

Interceptions Thrown(count)

—

2026 Roster Building Moves(deals)

14 reserve/future deals

—

Game Execution Rating(score)

Excellent - Clean execution

—

Win-Loss Record (2025 Season)(Record)

7-6

—

Points Per Game (2025 Season)(PPG)

24.3

—

Rushing Yards Per Game (2025 Season)(YPG)

108.2

—

Passing Yards Per Game (2025 Season)(YPG)

285.9

—

Points Allowed Per Game (2025 Season)(PPG)

22.8

—

Sacks Per Game (2025 Season)(SPG)

2.1

—

Turnovers Forced (2025 Season)(Total)

—

Third Down Conversion Rate (2025)(%)

42.1%

—

Full Comparison

Attribute	San Francisco 49ers	Indianapolis Colts

2025 Win-Loss Record(wins-losses)	13-4	8-9
Playoff Appearances (Last 5 Years)(appearances)	4	0
2025 Season Wins(wins)	12	—

Points Per Game (Offense)(PPG)	26.3	23.1

Points Allowed Per Game (Defense)(PPG)	18.2	24.7
Points Allowed Per Game (2025)(points)	18.9	—

Rushing Yards Per Game(yards)	134.2	108.6
Passing Yards Per Game(yards)	259.8	287.3
Average Passing Yards Per Game (2025)(yards)	234.2	—
Average Rushing Yards Per Game (2025)(yards)	148.7	—

Head Coach Winning Percentage(%)	71.4%	56.3%

Franchise Super Bowl Wins(total)	5	1
Super Bowl Appearances(total)	6	—

Head Coach Win Percentage(percent)	63.2%	—

Playoff Wins (Last 3 Seasons)(wins)	6	—

Team Payroll (2025 Approx)(millions)	$267M	—

Turnovers(count)	0	—
Fumbles Lost(count)	0	—
Total Turnovers (Fumbles + INTs)(count)	0	—
Fumbles (Total-Lost)(count)	0-0	—

Yards Per Play(yards)	3.9	—

Interceptions Thrown(count)	0	—

2026 Roster Building Moves(deals)	14 reserve/future deals	—

Game Execution Rating(score)	Excellent - Clean execution	—
Win-Loss Record (2025 Season)(Record)	7-6	—

Points Per Game (2025 Season)(PPG)	24.3	—
Rushing Yards Per Game (2025 Season)(YPG)	108.2	—
Passing Yards Per Game (2025 Season)(YPG)	285.9	—

Points Allowed Per Game (2025 Season)(PPG)	22.8	—
Sacks Per Game (2025 Season)(SPG)	2.1	—
Turnovers Forced (2025 Season)(Total)	18	—

Third Down Conversion Rate (2025)(%)	42.1%	—

San Francisco 49ers

Indianapolis Colts

2025 Win-Loss Record(wins-losses)

13-4

8-9

Playoff Appearances (Last 5 Years)(appearances)

2025 Season Wins(wins)

—

Points Per Game (Offense)(PPG)

26.3

23.1

Points Allowed Per Game (Defense)(PPG)

18.2

24.7

Points Allowed Per Game (2025)(points)

18.9

—

Rushing Yards Per Game(yards)

134.2

108.6

Passing Yards Per Game(yards)

259.8

287.3

Average Passing Yards Per Game (2025)(yards)

234.2

—

Average Rushing Yards Per Game (2025)(yards)

148.7

—

Head Coach Winning Percentage(%)

71.4%

56.3%

Franchise Super Bowl Wins(total)

Super Bowl Appearances(total)

—

Head Coach Win Percentage(percent)

63.2%

—

Playoff Wins (Last 3 Seasons)(wins)

—

Team Payroll (2025 Approx)(millions)

$267M

—

Turnovers(count)

—

Fumbles Lost(count)

—

Total Turnovers (Fumbles + INTs)(count)

—

Fumbles (Total-Lost)(count)

0-0

—

Yards Per Play(yards)

3.9

—

Interceptions Thrown(count)

—

2026 Roster Building Moves(deals)

14 reserve/future deals

—

Game Execution Rating(score)

Excellent - Clean execution

—

Win-Loss Record (2025 Season)(Record)

7-6

—

Points Per Game (2025 Season)(PPG)

24.3

—

Rushing Yards Per Game (2025 Season)(YPG)

108.2

—

Passing Yards Per Game (2025 Season)(YPG)

285.9

—

Points Allowed Per Game (2025 Season)(PPG)

22.8

—

Sacks Per Game (2025 Season)(SPG)

2.1

—

Turnovers Forced (2025 Season)(Total)

—

Third Down Conversion Rate (2025)(%)

42.1%

—

San Francisco 49ers vs Indianapolis Colts

San Francisco 49ers

Indianapolis Colts

Short Answer

Our Verdict

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Key Differences at a Glance

Key Facts & Figures

Key Differences

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Pros & Cons

San Francisco 49ers

Pros

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Indianapolis Colts

Pros

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San Francisco 49ers vs Indianapolis Colts

San Francisco 49ers

Indianapolis Colts

Short Answer

Our Verdict

🔔Track this comparison

Key Differences at a Glance

Key Facts & Figures

Key Differences

Related Comparisons

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Full Comparison

Visual Comparison

Pros & Cons

San Francisco 49ers

Pros

Cons

Indianapolis Colts

Pros

Cons

Frequently Asked Questions

Resources & Learn More

Learn More

Wikipedia

Videos

Full Comparison

Visual Comparison

Track this comparison