OTC pain reliever, active ingredient acetaminophen
Headaches, fever, mild pain, stomach-sensitive individuals
OTC NSAID pain reliever and anti-inflammatory
Muscle aches, arthritis, inflammation, menstrual pain
Tylenol (acetaminophen) relieves pain and fever without anti-inflammatory effects and is gentler on the stomach. Advil (ibuprofen) is an NSAID that reduces pain, fever, AND inflammation, making it better for muscle aches and arthritis.
Tylenol is safer for people with stomach issues or those taking blood thinners. Advil is better for inflammation-based pain. Consult a doctor for chronic use of either.
Choose Tylenol (Acetaminophen) if
Headaches, fever, mild pain, stomach-sensitive individuals
Get notified when prices change, new specs ship, or our verdict updates.
Triggers: price change new spec verdict update
No spam. Stop anytime.
| Metric | Tylenol (Acetaminophen) | Advil (Ibuprofen) | Diff |
|---|---|---|---|
| Duration of Effect(hours) | 4-6 | 6-8 | -29% |
All figures sourced from publicly available data. Last updated May 2026.
Almond Milk vs Oat Milk
health
Vegan vs Vegetarian
health
Keto vs Paleo
health
Running vs Walking
health
Wegovy vs Ozempic
health
Yoga vs Pilates
health
CrossFit vs Gym Training
health
Flu Shot vs COVID Vaccine
health
Organic Food vs Non-Organic Food
health
Therapy vs Medication
health
Meditation vs Yoga
health
Contact Lenses vs Glasses
health
Choose Advil (Ibuprofen) if
Muscle aches, arthritis, inflammation, menstrual pain
Tylenol (Acetaminophen)
No
Advil (Ibuprofen)
Yes🏆
Tylenol (Acetaminophen)
Better🏆
Advil (Ibuprofen)
Can irritate
Tylenol (Acetaminophen)
4-6 hours
Advil (Ibuprofen)
6-8 hours🏆
Tylenol (Acetaminophen)
2nd trimester only🏆
Advil (Ibuprofen)
Avoid 3rd trimester
Tylenol (Acetaminophen)
Liver damage
Advil (Ibuprofen)
GI/kidney issues
Both work for headaches. Tylenol is gentler on the stomach; Advil may work better if tension is involved.
Dive deeper with these curated resources
As an affiliate, we may earn a commission from qualifying purchases at no extra cost to you. Learn more
| Attribute | Tylenol (Acetaminophen) | Advil (Ibuprofen) |
|---|---|---|
| Standard Dose | 325-650mg every 4-6h | 200-400mg every 4-6h |
| Anti-inflammatory | No | Yes |
| Duration of Effect(hours) | 4-6 | 6-8 |
Side-by-side comparison of numeric attributes