49ers vs Rams 2026: Rivalry History, Head-to-Head Stats & Key Matchups

The San Francisco 49ers lead the all-time series over the Los Angeles Rams 70-55, with a 15-9 edge since the Rams returned to Los Angeles in 2016. The most defining modern rivalry moment: the 2022 NFC Championship Game where the Rams defeated the 49ers 20-17 in overtime at SoFi Stadium before winning Super Bowl LVI. In 2026, both franchises enter with NFC West seeding implications as the stakes — Brock Purdy and Kyle Shanahan's scheme diversity vs. the Rams' passing attack anchored by Matthew Stafford and Cooper Kupp.