The 49ers and Rams are NFC West division rivals with different roster strengths in 2025-2026: the 49ers excel in defensive depth and rushing attack while the Rams leverage their passing game and recent acquisitions. Head-to-head performance varies significantly based on injury status and seasonal momentum.
San Francisco 49ers vs Los Angeles Rams — Side-by-side comparison on A Versus B
NFC West powerhouse with elite defense and rushing attack led by Christian McCaffrey.
Offensive-minded division rival featuring Matthew Stafford and multiple Pro Bowl-caliber receivers.
2025 Season Wins (Regular Season). Rushing Yards Per Game Leader. Passing Touchdowns (QB). Total Defense Ranking (2025). Pass Completion Percentage. Sacks Allowed (Offensive Line). Points Per Game Scored
The 49ers edge out the Rams in 2025 with a superior defense (5th vs 14th ranked), elite rushing game via McCaffrey (123.2 YPG), and stronger regular season record (12-5 vs 10-7). However, the Rams maintain a pass-happy offensive approach with Stafford's 31 TDs and feature dangerous receivers. Choose the 49ers if you prioritize defensive consistency and ground-game dominance; choose the Rams if you value high-volume passing offense and explosive playmakers.
San Francisco 49ers: 13-4 | Los Angeles Rams: N/A
San Francisco 49ers: 27.3 | Los Angeles Rams: 25.8
San Francisco 49ers: 18.2 | Los Angeles Rams: N/A
San Francisco 49ers: 259.8 | Los Angeles Rams: N/A
San Francisco 49ers: 4 | Los Angeles Rams: N/A
San Francisco 49ers: 71.4% | Los Angeles Rams: N/A
San Francisco 49ers: 5 | Los Angeles Rams: N/A
San Francisco 49ers: 12 | Los Angeles Rams: 11
San Francisco 49ers: 234.2 | Los Angeles Rams: 268.5
San Francisco 49ers: 148.7 | Los Angeles Rams: 98.3
San Francisco 49ers: 18.9 | Los Angeles Rams: 21.4
San Francisco 49ers: 6 | Los Angeles Rams: 2
San Francisco 49ers: 63.2% | Los Angeles Rams: 59.8%
San Francisco 49ers: $267M | Los Angeles Rams: $284M
San Francisco 49ers: 0 | Los Angeles Rams: N/A
San Francisco 49ers: 3.9 | Los Angeles Rams: N/A
San Francisco 49ers: 14 reserve/future deals | Los Angeles Rams: N/A
San Francisco 49ers: Excellent - Clean execution | Los Angeles Rams: N/A
San Francisco 49ers: 0-0 | Los Angeles Rams: N/A
San Francisco 49ers: 64.5% | Los Angeles Rams: N/A
San Francisco 49ers: Brock Purdy 2,167 yards | Los Angeles Rams: N/A
San Francisco 49ers: 19.0 | Los Angeles Rams: N/A
San Francisco 49ers: 75.0% | Los Angeles Rams: N/A
San Francisco 49ers: 69.4% (Brock Purdy) | Los Angeles Rams: N/A
San Francisco 49ers: Christian McCaffrey depth role | Los Angeles Rams: N/A
San Francisco 49ers: 80 seasons overall | Los Angeles Rams: N/A
San Francisco 49ers: 5 championships | Los Angeles Rams: 2
San Francisco 49ers: 12-5 (.706 winning %) | Los Angeles Rams: 11-6 (.647 winning %)
San Francisco 49ers: 5 consecutive | Los Angeles Rams: 3 total
San Francisco 49ers: 3 | Los Angeles Rams: N/A
San Francisco 49ers: 14 | Los Angeles Rams: N/A
San Francisco 49ers: 7 seasons (Kyle Shanahan, 2017-present) | Los Angeles Rams: N/A
San Francisco 49ers: $8.1B | Los Angeles Rams: N/A
San Francisco 49ers: 641-618 | Los Angeles Rams: 600-661
San Francisco 49ers: 1995 | Los Angeles Rams: 2022
San Francisco 49ers: Kyle Shanahan .606 (54-35) | Los Angeles Rams: Sean McVay .516 (49-46)
San Francisco 49ers: 16 | Los Angeles Rams: 13
San Francisco 49ers: 19 | Los Angeles Rams: 8
San Francisco 49ers: 13 | Los Angeles Rams: N/A
San Francisco 49ers: 4,694 (Brock Purdy) | Los Angeles Rams: N/A
QB Touchdown-to-Interception Ratio (2024)
San Francisco 49ers: 3.44 (31 TDs / 9 INTs) | Los Angeles Rams: N/A
San Francisco 49ers: 12-5 (4th seed, NFC) | Los Angeles Rams: N/A
San Francisco 49ers: 8 seasons (Kyle Shanahan, since 2017) | Los Angeles Rams: N/A
San Francisco 49ers: 19 | Los Angeles Rams: N/A
San Francisco 49ers: .525 (586-529-16) | Los Angeles Rams: N/A
San Francisco 49ers: 12-5 (.706) | Los Angeles Rams: N/A
San Francisco 49ers: 7 appearances | Los Angeles Rams: N/A
San Francisco 49ers: 14 Hall of Famers | Los Angeles Rams: N/A
San Francisco 49ers: 107.2 (Brock Purdy) | Los Angeles Rams: N/A
San Francisco 49ers: 1st Place NFC West | Los Angeles Rams: N/A
San Francisco 49ers: 1 year (2024 won) | Los Angeles Rams: N/A
San Francisco 49ers: 25.1 | Los Angeles Rams: N/A
San Francisco 49ers: 4,694 (Purdy leader) | Los Angeles Rams: N/A
San Francisco 49ers: 1,459 (McCaffrey leader) | Los Angeles Rams: N/A
San Francisco 49ers: 12th - 226.5 YPG allowed | Los Angeles Rams: N/A
San Francisco 49ers: 48 | Los Angeles Rams: N/A
San Francisco 49ers: 16 | Los Angeles Rams: N/A
San Francisco 49ers: 68.2% (Purdy) | Los Angeles Rams: N/A
San Francisco 49ers: 72% | Los Angeles Rams: N/A
San Francisco 49ers: 12-5 | Los Angeles Rams: 10-7
San Francisco 49ers: 123.2 | Los Angeles Rams: 98.7
San Francisco 49ers: 28 | Los Angeles Rams: 31
San Francisco 49ers: 67.4% | Los Angeles Rams: 68.9%
San Francisco 49ers: 5th | Los Angeles Rams: 14th
San Francisco 49ers: 28 | Los Angeles Rams: 32
San Francisco 49ers: 52% run | Los Angeles Rams: 38% run
How to choose between San Francisco 49ers and Los Angeles Rams
Compare San Francisco 49ers vs Los Angeles Rams
San Francisco 49ers vs Los Angeles Rams — Structured Comparison Data
Machine-readable comparison dataset for San Francisco 49ers vs Los Angeles Rams. Contains 71 attribute comparisons, 5 FAQ pairs.
San Francisco 49ers vs Los Angeles Rams — Attribute Category Vocabulary
Taxonomy of attribute categories used to classify comparison data for San Francisco 49ers vs Los Angeles Rams.
Who won the last head-to-head matchup between 49ers and Rams in 2025?
In their 2025 regular season meetings, the 49ers defeated the Rams twice (both divisional matchups), leveraging their superior defense and McCaffrey's rushing dominance to control the line of scrimmage.
Which team has better playoff odds for the 2025-2026 season?
The 49ers hold better playoff positioning with their 12-5 record, 5th-ranked defense, and first-place division standing, while the Rams at 10-7 remain a Wild Card contender dependent on late-season performance.
How do their pass-catching options compare?
The Rams feature a more elite receiving corps with Puka Nacua and Cooper Kupp (both Pro Bowl caliber), while the 49ers rely more heavily on tight end George Kittle (1,100+ receiving yards) and complimentary receivers, reflecting their ground-first offensive philosophy.
Which defense is stronger against the run?
The 49ers rank significantly higher defensively (5th overall), particularly excelling against the run with Nick Bosa and elite defensive line depth, allowing 3.8 yards per carry versus the Rams' 4.2 YPC allowed.
What is the injury status impact on both teams?
The 49ers face concerns with offensive line depth following injuries to key starters, affecting pass protection, while the Rams have invested heavily in recent defensive acquisitions to address their 14th-ranked defense, creating roster depth variations.
How to Choose Between San Francisco 49ers and Los Angeles Rams
Consider: 2025 Season Wins (Regular Season)
2025 Season Wins (Regular Season): San Francisco 49ers has 12 wins, while Los Angeles Rams has 10 wins.
Rushing Yards Per Game Leader: San Francisco 49ers has Christian McCaffrey - 123.2 YPG, while Los Angeles Rams has Kyren Williams - 98.7 YPG.
Passing Touchdowns (QB): San Francisco 49ers has Brock Purdy - 28 TD, while Los Angeles Rams has Matthew Stafford - 31 TD.
Total Defense Ranking (2025): San Francisco 49ers has 5th in NFL, while Los Angeles Rams has 14th in NFL.
Pass Completion Percentage: San Francisco 49ers has Purdy - 67.4%, while Los Angeles Rams has Stafford - 68.9%.
Consider: Sacks Allowed (Offensive Line)
Sacks Allowed (Offensive Line): San Francisco 49ers has 28 sacks allowed, while Los Angeles Rams has 32 sacks allowed.
Points Per Game Scored: San Francisco 49ers has 27.3 PPG, while Los Angeles Rams has 25.8 PPG.